商品介绍
BIOLOGICAL INFORMATION
DescriptionSubstance P (SP) is an endogenous tachykinin neuropeptide that is involved in inflammatory, pain, and stress signaling; it exhibits neuroprotective, cognition enhancing, and gastrointestinal motility modulating activities. SP exhibits neuroprotective activity by decreasing expression of Kv1.4 K+ channels in transgenic animal models of Alzheimer’s disease and improving cognitive performance in the Morris water maze task. SP is the natural ligand for the neurokinin-1 (NK1) receptor. In various animal models, SP modulates opioid signaling, induces gastric mucosal protection, and inhibits retinal apoptosis. SP also prevents hyperoxia-induced lung damage, decreasing levels of malondialdehyde and increasing levels of superoxide dismutase (SOD); this activity may be regulated through SHH signaling. In melanoma cells, SP decreases levels of tyrosinase and melanin, inhibiting melanogenesis. In other cellular models, SP increases the viability and proliferation of osteoblasts and promotes gap junction intracellular communication.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10862
CAS No.71977-09-8
NameSubstance P, Free Acid
Chemical NameSubstance-P,-Free-Acid
Purity≥98%
SynonymsN/A
FormulaC63H97N17O14S
Molecular Weight1348.7
One Letter CodeRPKPQQFFGLM
Three Letter CodeARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
SMILESCC(C)CC(C(=O)NC(CCSC)C(=O)O)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N
InChI KeyXHWDVRRNQHMAPE-CUZNLEPHSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingIce Pack
Stability≥ 2 years
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
品牌介绍
Ontores化妆品肽的多功能特性，包括调节某些生物学功能的能力，正在引领着一场美容革命。科学文献报道某些肽可以充当细胞信使。这些肽能够刺激胶原蛋白的产生并调节胶原蛋白降解所涉及的酶。Ontores能够提供多种生物活性化妆品肽，还可以提供有关化妆品配方的咨询服务。请查看我们的一些最受欢迎的美容肽清单。如果您有不同的化妆品肽合成要求，请告知我们肽序列，所需纯度和所需数量。我们的销售团队会尽快与您联系！
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